ANTIBODY SIGNALING IN IMMUNITY

What We Do

We investigate how antibody signaling regulates innate and adaptive immunity. Our research combines antibody and immune cell engineering, identification of signaling mechanisms that drive different disease outcomes, and exploration of how glycosylation of antibodies and their receptors influences immune function. By defining these pathways, we aim to enhance vaccine efficacy and develop targeted, innovative therapies.

Maternal Anti-Dengue IgG Fucosylation Predicts Susceptibility to Dengue Disease in Infants	Sialylated IgG induces the transcription factor REST in alveolar macrophage to protect against lung	Sialylated hIgG reduces lung inflammation and protects lung function in influenza-infected mice. After infection, mice that received sialylated hIgG had reduced neutrophils and increased Amφ relative to those that received the virus alone.
Sialylated IgG blocks NF-κB and induces REST	IgG1 afucosylation is higher in participants that go on to develop dengue infection after Dengvaxia vaccination.	mRNA vaccination elicits high neutralizing antibody titers with Fc glycoforms distinct from infection-induced IgG phenotypes.

ANTIBODY SIGNALING IN IMMUNITY

Maternal Anti-Dengue IgG Fucosylation Predicts Susceptibility to Dengue Disease in Infants

Sialylated IgG induces the transcription factor REST in alveolar macrophage to protect against lung

Sialylated hIgG reduces lung inflammation and protects lung function in influenza-infected mice. After infection, mice that received sialylated hIgG had reduced neutrophils and increased Amφ relative to those that received the virus alone.

Sialylated IgG blocks NF-κB and induces REST

IgG1 afucosylation is higher in participants that go on to develop dengue infection after Dengvaxia vaccination.

mRNA vaccination elicits high neutralizing antibody titers with Fc glycoforms distinct from infection-induced IgG phenotypes.